English
norskBlar i forfatter "Vangberg, Torgil Riise"
Viser treff 1-20 av 21
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Anatomical variations in the circle of Willis are associated with increased odds of intracranial aneurysms: The Tromsø study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-25)Purpose: Studies on patients suggest an association between anatomical variations in the Circle of Willis (CoW) and intracranial aneurysms (IA), but it is unclear whether this association is present in the general population. In this cross-sectional population study, we investigated the associations between CoW anatomical variations and IA.<p> <p>Methods: We included 1667 participants from a ... -
The antidepressant effect of intermittent theta burst stimulation (iTBS): study protocol for a randomized double-blind sham-controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-02)Background Intermittent theta burst stimulation (iTBS) when applied over the left dorsolateral prefrontal cortex (DLPFC) has been shown to be equally effective and safe to treat depression compared to traditional repetitive transcranial magnetic stimulation (rTMS) paradigms. This protocol describes a funded single-centre, double-blind, randomized placebo-controlled, clinical trial to investigate ... -
Association of white matter integrity and gait speed during dual-tasking among community-dwelling elderly adults
(Conference object; Konferansebidrag, 2017) -
Both brain size and biological sex contribute to variation in white matter microstructure in middle-aged healthy adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-03)Whether head size and/or biological sex influence proxies of white matter (WM) microstructure such as fractional anisotropy (FA) and mean diffusivity (MD) remains controversial. Diffusion tensor imaging (DTI) indices are also associated with age, but there are large discrepancies in the spatial distribution and timeline of age-related differences reported. The aim of this study was to evaluate the ... -
Cerebral cortical dimensions in headache sufferers aged 50-66 years: a population-based imaging study in the Nord-Trondelag Health Study (HUNT-MRI)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07)Based on previous clinic-based magnetic resonance imaging studies showing regional differences in the cerebral cortex between those with and without headache, we hypothesized that headache sufferers have a decrease in volume, thickness, or surface area in the anterior cingulate cortex, prefrontal cortex, and insula. In addition, exploratory analyses on volume, thickness, and surface area across the ... -
Cerebral cortical thickness and surface area in adolescent anorexia nervosa: Separate and joint analyses with a permutation-based nonparametric method
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-17)<i>Objective</i> - Reduction in cerebral volume is often found in underweight patients with anorexia nervosa (AN), but few studies have investigated other morphological measures. Cortical thickness (CTh) and surface area (CSA), often used to produce the measure of cortical volume, are developmentally distinct measures that may be differentially affected in AN, particularly in the developing brain. ... -
The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-04)Even though age-related white matter hyperintensities (WMH) begin to emerge in middle age, their effect on brain micro- and macrostructure in this age group is not fully elucidated. We have examined how presence of WMH and load of WMH affect regional brain volumes and microstructure in a validated, representative general population sample of 873 individuals between 50 and 66 years. Presence of WMH ... -
Five years of exercise intervention at different intensities and development of white matter hyperintensities in community dwelling older adults, a Generation 100 sub-study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-18)We investigated if a five-year supervised exercise intervention with moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT) versus control; physical activity according to national guidelines, attenuated the growth of white matter hyperintensities (WMH). We hypothesized that supervised exercise, in particular HIIT, reduced WMH growth. Older adults from the general ... -
High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer’s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-14)Background: The optimal stimulation parameters when using transcranial direct current stimulation (tDCS) to improve memory performance in patients with Alzheimer’s disease (AD) are lacking. In healthy individuals, inter-individual differences in brain anatomy significantly influence current distribution during tDCS, an effect that might be aggravated by variations in cortical atrophy in AD ... -
Hippocampal Subfields in Adolescent Anorexia Nervosa
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-25)Patients with anorexia nervosa (AN) exhibit volume reduction in cerebral gray matter (GM), and several studies report reduced hippocampus volume. The hippocampal subfields (HS) are functionally and structurally distinct, and appear to respond differently to neuropathology. The aim of this study was to investigate HS volumes in adolescent females with restrictive AN compared to a healthy age-matched ... -
An incomplete Circle of Willis is not a risk factor for white matter hyperintensities: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)<p><i>Objective - </i>The Circle of Willis (CoW) is often underdeveloped or incomplete, leading to suboptimal blood supply to the brain. As hypoperfusion is thought to play a role in the aetiology of white matter hyperintensities (WMH), the objective of this study was to assess whether incomplete CoW variants were associated with increased WMH volumes compared to the complete CoW. <p><i>Methods - ... -
Machine-learning-derived heart and brain age are independently associated with cognition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-31)Background and purpose - A heart age biomarker has been developed using deep neural networks applied to electrocardiograms. Whether this biomarker is associated with cognitive function was investigated.<p> <p>Methods - Using 12-lead electrocardiograms, heart age was estimated for a population-based sample (N = 7779, age 40–85 years, 45.3% men). Associations between heart delta age (HDA) and ... -
Magnetic resonance volumetry: prediction of subjective memory complaints and mild cognitive impairment, and associations with genetic and cardiovascular risk factors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)<i>Background/Aims</i>: Subjective memory complaints (SMC) are strong predictors of mild cognitive impairment (MCI) and subsequent Alzheimer’s disease. Our aims were to see if fully automated cerebral MR volume measurements could distinguish subjects with SMC and MCI from controls, and if probable parental late-onset Alzheimer’s disease (LOAD), apolipoprotein E ε4 genotype, total plasma homocysteine, ... -
Prevalence of intracranial artery stenosis in a general population using 3D-time of flight magnetic resonance angiography
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-20)Background: Data on prevalence of intracranial artery stenosis (ICAS) in Western populations is sparse. The aim of the study was to assess the prevalence and risk factors for ICAS in a mainly Caucasian general population. Methods: We assessed the prevalence of ICAS in 1847 men and women aged 40 to 84 years who participated in a cross-sectional population-based study, using 3-dimensional time-of-flight ... -
Prevalence of unruptured intracranial aneurysms: impact of different definitions-the Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-10)Background - Management of incidental unruptured intracranial aneurysms (UIAs) remains challenging and depends on their risk of rupture, estimated from the assumed prevalence of aneurysms and the incidence of aneurysmal subarachnoid haemorrhage. Reported prevalence varies, and consistent criteria for definition of UIAs are lacking. We aimed to study the prevalence of UIAs in a general population ... -
The relation of hippocampal subfield volumes to verbal episodic memory measured by the California Verbal Learning Test II in healthy adults
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-06-08)Total hippocampal volume has previously been shown to correlate with performance on tests for verbal episodic memory. However, there are sparse evidence on how hippocampal subfield volumes are related to verbal episodic memory in healthy adults. The present study investigated the association between volumes of separate hippocampal subfields and verbal episodic memory performance in healthy volunteers. ... -
Relevance of cognition to health-related quality of life in good-outcome surviors of out-of-hospital cardiac arrest
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-10-05)<p>Objective: For survivors of out-of-hospital cardiac arrest (OHCA) with good outcomes, it is not known whether and how health-related quality of life is affected by the cognitive impairments frequently observed in these patients. This study explores how neuropsychological tests of memory, executive and psychomotor functioning relate to the physical and mental aspects of health-related quality ... -
The role of moderating variables on BOLD fMRI response during semantic verbal fluency and finger tapping in active and educated healthy seniors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)Semantic verbal fluency is among the most employed tasks in cognitive aging research and substantial work is devoted to understanding the underlying mechanisms behind age-related differences at the neural and behavioral levels. The present investigation aimed to evaluate the role of moderating variables, such as age, sex, MMSE, and proxies of cognitive reserve (CR) on the hemodynamic response evoked ... -
Variations in the Circle of Willis in a large population sample using 3D TOF angiography: The Tromsø Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)The main arteries that supply blood to the brain originate from the Circle of Willis (CoW). The CoW exhibits considerable anatomical variations which may have clinical importance, but the variability is insufficiently characterised in the general population. We assessed the anatomical variability of CoW variants in a community-dwelling sample (N = 1,864, 874 men, mean age = 65.4, range 40–87 years), ... -
What does hand motor function tell us about our aging brain in association with WMH?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-29)<i>Background</i> - White matter hyperintensities (WMH) are a common cerebral finding in older people. WMH are usually asymptomatic, but excessive WMH are associated with cognitive decline and dementia. WMH are also among the neurological findings most consistently associated with declining motor performance in healthy ageing.<br><br> <i>Aims</i> - To determine if WMH load is associated with ...
